influence of sexuality in functional recovery after spinal cord injury in rats

نویسندگان

mohammadreza emamhadi department of neurosurgery, guilan university of medical sciences, rasht, iran

bahram soltani department of p harmacology, cellular and molecular research center, guilan university of medical sciences, rasht, iran

parvin babaei department of physiology, cellular and molecular research center, guilan university of medical sciences, rasht, iran

hossein mashhadinezhad department of neurosurgery, ghaem hospital, mashhad, iran

چکیده

background: spinal cord injury (sci) is a major clinical condition and research is commonly done to find suitable treatment options. however, there are some degrees of spontaneous recovery after sci and gender is said to be a contributing factor in recovery, but this is controversial. this study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury in wistar rats. methods: spinal cord lesions were made by compressing the cord at t9 level and making a spinal cord contusion. routine care of each rat was done daily. the lss scoring system was used to measure the locomotion of these rats and to compare the recovery rate between male and female rats. results: the results suggested that there was no significant difference between the two sex in recovery. conclusions: to be female does not seem to be a prognostic factor for recovery after sci. however, this preliminary study should be repeated in other animals and in larger cohorts.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Influence of Sexuality in Functional Recovery after Spinal Cord Injury in rats

  Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...

متن کامل

Influence of Sexuality in Functional Recovery after Spinal Cord Injury in Rats.

BACKGROUND Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury...

متن کامل

Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions

Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...

متن کامل

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewe...

متن کامل

Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats

Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effect. Spinal cord injury was induced by impacting the spinal cord at the thoracic T10 vertebra level...

متن کامل

Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats.

Blocking the action of inhibitory molecules at sites of central nervous system injury has been proposed as a strategy to promote axonal regeneration and functional recovery. We have previously shown that genetic deletion or competitive antagonism of EphA4 receptor activity promotes axonal regeneration and functional recovery in a mouse model of lateral hemisection spinal cord injury. Here we ha...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
the archives of bone and joint surgery

جلد ۴، شماره ۱، صفحات ۵۶-۵۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023